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In patients with T2DM who are overweight or obese, glucagonlike peptide 1 (GLP-1) and dual GLP-1/gastric inhibitory peptide (GIP) agonists are used as adjunct or alternative therapies given their dual benefits for insulin sensitivity and weight loss

As TRAIL-expressing astrocytes have been previously demonstrated to induce T-cell apoptosis and downstream CNS inflammation, notably, the expression of this receptor was dependent on meningeal IFN expression from NK cells, and the microbiota was known to induce IFN expression from NK cells (Sanmarco et al., 2021)

Chronic pain can make it difficult to perform daily activities such as working, sleeping or enjoying other leisure activities